Tonapofylline
Modify Date: 2024-01-10 09:02:31
Tonapofylline structure
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Common Name | Tonapofylline | ||
|---|---|---|---|---|
| CAS Number | 340021-17-2 | Molecular Weight | 416.51400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H32N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TonapofyllineTonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure[1][2]. |
| Name | Tonapofylline |
|---|---|
| Synonym | More Synonyms |
| Description | Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure[1][2]. |
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| Related Catalog | |
| Target |
Ki: 7.4 nM (Human adenosine A1 receptor)[1] |
| References |
| Molecular Formula | C22H32N4O4 |
|---|---|
| Molecular Weight | 416.51400 |
| Exact Mass | 416.24200 |
| PSA | 109.98000 |
| LogP | 3.16310 |
| Storage condition | -20°C |
| 3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-proprionic acid |
| 4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1,3-DIPROPYL-1H-PURIN-8-YL)-BICYCLO[2.2.2]OCTANE-1-PROPANOIC ACID |
| 3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-propionic acid |