Picotamide structure
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Common Name | Picotamide | ||
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CAS Number | 32828-81-2 | Molecular Weight | 376.40900 | |
Density | 1.246g/cm3 | Boiling Point | 668.1ºC at 760mmHg | |
Molecular Formula | C21H20N4O3 | Melting Point | 124ºC | |
MSDS | Chinese USA | Flash Point | 357.8ºC |
Use of PicotamidePicotamide is a combined inhibitor of thromboxane A2 (TxA2) synthase and receptor. Picotamide has antiplatelet activity. Picotamide promotes the reduction of microalbuminuria and the inhibition of growth of carotid plaques in diabetes. Picotamide can be used for researching acute or chronic cardiovascular diseases[1]. |
Name | 4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide |
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Synonym | More Synonyms |
Description | Picotamide is a combined inhibitor of thromboxane A2 (TxA2) synthase and receptor. Picotamide has antiplatelet activity. Picotamide promotes the reduction of microalbuminuria and the inhibition of growth of carotid plaques in diabetes. Picotamide can be used for researching acute or chronic cardiovascular diseases[1]. |
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Related Catalog | |
References |
Density | 1.246g/cm3 |
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Boiling Point | 668.1ºC at 760mmHg |
Melting Point | 124ºC |
Molecular Formula | C21H20N4O3 |
Molecular Weight | 376.40900 |
Flash Point | 357.8ºC |
Exact Mass | 376.15400 |
PSA | 93.21000 |
LogP | 3.12700 |
Index of Refraction | 1.614 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
RTECS | CZ2235500 |
HS Code | 2933399090 |
HS Code | 2933399090 |
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Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism.
Thromb. Haemost. 78(5) , 1385-91, (1997) Picotamide is a dual thromboxane (Tx) A2 receptor antagonist/Tx synthase inhibitor although some observations suggest an anti-vasoconstrictor effect independent of TxA2 inhibition/antagonism. The aim ... |
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Determinants of fibrinogen in an Italian population suffering from claudication. Lower fibrinogen in the south compared to middle and north of Italy. The ADEP Group.
Haematologica 83(8) , 701-7, (1998) Prospective studies have shown that high plasma levels of fibrinogen are independently associated with the risk of cardiovascular complications. In patients suffering from peripheral vascular disease ... |
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Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure.
J. Am. Coll. Cardiol. 42(1) , 133-9, (2003) The aim of this study was to evaluate whether thromboxane inhibition can favorably affect renal perfusion and clinical conditions in patients affected by severe heart failure.The renal formation of th... |
EINECS 251-245-7 |
MFCD00866792 |
4-methoxy-N,N'-bis-pyridin-3-ylmethyl-isophthalamide |
Plactidil |
picotamide |
4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide |
G 137 |