Ceefourin 1
Modify Date: 2025-08-25 21:12:57
Ceefourin 1 structure
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Common Name | Ceefourin 1 | ||
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| CAS Number | 315702-40-0 | Molecular Weight | 294.419 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 422.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C11H10N4S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 209.1±31.5 °C | |
Use of Ceefourin 1Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma[1][2]. |
| Name | 5-(Benzothiazol-2-ylsulfanylmethyl)-4-methyl-4H-[1,2,4]triazole-3-thiol |
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| Synonym | More Synonyms |
| Description | Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma[1][2]. |
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| Related Catalog | |
| Target |
MRP4[1] |
| In Vitro | Ceefourin 1 are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (ABCC1). Ceefourin 1 has limited off-target effects and high stability[1]. Ceefourin 1 (100 nM-100 μM) has low cellular toxicity (IC50>50) in two normal (HSF, MRC5), seven neuroblastoma (BE(2)-C, IMR-32, LAN-1, IMR-32, SK-N-SH, NBL-WN, SHEP) and four other human cancer cell lines (HEPG2, LNCap, SJ-G2, MCF7)[1]. Ceefourin 1 has an IC50 of 2.5 μM in HEK293 cell. Ceefourin 1 blocks D-luciferin efflux with an IC50 of 1.5 μM[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 422.1±55.0 °C at 760 mmHg |
| Molecular Formula | C11H10N4S3 |
| Molecular Weight | 294.419 |
| Flash Point | 209.1±31.5 °C |
| Exact Mass | 294.006744 |
| LogP | 1.85 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.827 |
| InChIKey | KVNBVHCJAUXKPJ-UHFFFAOYSA-N |
| SMILES | Cn1c(CSc2nc3ccccc3s2)n[nH]c1=S |
| MFCD03984494 |
| 3H-1,2,4-Triazole-3-thione, 5-[(2-benzothiazolylthio)methyl]-2,4-dihydro-4-methyl- |
| 5-(Benzothiazol-2-ylsulfanylmethyl)-4-methyl-4H-[1,2,4]triazole-3-thiol |
| 5-[(1,3-Benzothiazol-2-ylsulfanyl)methyl]-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione |