Brecanavir

Modify Date: 2024-01-09 15:10:20

Brecanavir structure	Common Name	Brecanavir
	CAS Number	313682-08-5	Molecular Weight	703.82300
	Density	1.43g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₁N₃O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Brecanavir

Brecanavir (GW640385) is a novel, potent HIV protease inhibitor.

Name	[(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate
Synonym	More Synonyms

Description

Brecanavir (GW640385) is a novel, potent HIV protease inhibitor.

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

References

[1]. Ford SL, Reddy YS, Anderson MT, et al. Single-dose safety and pharmacokinetics of brecanavir, a novel human immunodeficiency virus protease inhibitor. Antimicrob Agents Chemother. 2006;50(6):2201-2206.

[2]. Reddy YS, Ford SL, Anderson MT, Murray SC, Ng-Cashin J, Johnson MA. Safety and pharmacokinetics of brecanavir, a novel human immunodeficiency virus type 1 protease inhibitor, following repeat administration with and without ritonavir in healthy adult subjects. Antimicrob Agents Chemother. 2007;51(4):1202-1208.

Density	1.43g/cm3
Molecular Formula	C₃₃H₄₁N₃O₁₀S₂
Molecular Weight	703.82300
Exact Mass	703.22300
PSA	191.60000
LogP	5.33740
Index of Refraction	1.641

(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-[4-(benzyloxy)benzyl]-2-hydroxypropylcarbamate structure

(3R,3AS,6AR)-he...

CAS#:313679-55-9

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Brecanavir Structure

Brecanavir

CAS#:313682-08-5

Literature: Miller, John F.; Andrews, C. Webster; Brieger, Michael; Furfine, Eric S.; Hale, Michael R.; Hanlon, Mary H.; Hazen, Richard J.; Kaldor, Istvan; McLean, Ed W.; Reynolds, David; Sammond, Douglas M.; Spaltenstein, Andrew; Tung, Roger; Turner, Elizabeth M.; Xu, Robert X.; Sherrill, Ronald G. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1788 - 1794

N-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-oxycarbonyl-, (4S,5R)-4-(4-benzyloxy-benzyl)-5-i-butyl-[(3,4-methylenedioxyphenyl)sulfonyl]-aminomethyl-2,2-dimethyl-oxazolidine structure

N-(3R,3aS,6aR)-...

CAS#:313682-03-0

~%

Brecanavir Structure

Brecanavir

CAS#:313682-08-5

Literature: Miller, John F.; Andrews, C. Webster; Brieger, Michael; Furfine, Eric S.; Hale, Michael R.; Hanlon, Mary H.; Hazen, Richard J.; Kaldor, Istvan; McLean, Ed W.; Reynolds, David; Sammond, Douglas M.; Spaltenstein, Andrew; Tung, Roger; Turner, Elizabeth M.; Xu, Robert X.; Sherrill, Ronald G. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1788 - 1794

N/A structure

N/A

CAS#:313682-07-4

~%

Brecanavir Structure

Brecanavir

CAS#:313682-08-5

Literature: Miller, John F.; Andrews, C. Webster; Brieger, Michael; Furfine, Eric S.; Hale, Michael R.; Hanlon, Mary H.; Hazen, Richard J.; Kaldor, Istvan; McLean, Ed W.; Reynolds, David; Sammond, Douglas M.; Spaltenstein, Andrew; Tung, Roger; Turner, Elizabeth M.; Xu, Robert X.; Sherrill, Ronald G. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1788 - 1794

(3R,3aS,6aR)hexahydrofuro[2,3-b]furan-3-yl (4S,5R)-5-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-4-(4-hydroxybenzyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate structure

(3R,3aS,6aR)hex...

CAS#:313681-84-4

~%

Brecanavir Structure

Brecanavir

CAS#:313682-08-5

Literature: Miller, John F.; Andrews, C. Webster; Brieger, Michael; Furfine, Eric S.; Hale, Michael R.; Hanlon, Mary H.; Hazen, Richard J.; Kaldor, Istvan; McLean, Ed W.; Reynolds, David; Sammond, Douglas M.; Spaltenstein, Andrew; Tung, Roger; Turner, Elizabeth M.; Xu, Robert X.; Sherrill, Ronald G. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1788 - 1794

Brecanavir

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GW0385

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GW640385
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Brecanavir
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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