Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

Modify Date: 2025-09-06 16:49:34

Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]- structure	Common Name	Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
	CAS Number	3123-89-5	Molecular Weight	384.42600
	Density	1.28g/cm3	Boiling Point	722.2ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₄N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	390.6ºC

Name	N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonym	More Synonyms

Density	1.28g/cm3
Boiling Point	722.2ºC at 760 mmHg
Molecular Formula	C₂₁H₂₄N₂O₅
Molecular Weight	384.42600
Flash Point	390.6ºC
Exact Mass	384.16900
PSA	99.88000
LogP	3.41730
Index of Refraction	1.61
InChIKey	JWDFWIZNGSOUGC-INIZCTEOSA-N
SMILES	COc1cc2c(c(OC)c1OC)-c1ccc(N)c(=O)cc1C(NC(C)=O)CC2

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0710000

CHEMICAL NAME :: Colchicine, 10-amino-10-demethoxy-

CAS REGISTRY NUMBER :: 3123-89-5

BEILSTEIN REFERENCE NO. :: 2824077

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H24-N2-O5

MOLECULAR WEIGHT :: 384.47

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29600 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 98,236,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 8900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 160 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 12 mg/kg/24D-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified)

REFERENCE :: CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 93,188,1980

Colchicine

CAS#:64-86-8

~60%

Acetamide,N-[(7...

CAS#:3123-89-5

Literature: UNIVERSITY OF BRADFORD Patent: WO2008/125800 A2, 2008 ; Location in patent: Page/Page column 16 ;

Colchicine

CAS#:64-86-8

Ammonia

CAS#:7664-41-7

Acetamide,N-[(7...

CAS#:3123-89-5

Literature: Santavy Chemicke Listy, 1952 , vol. 46, p. 280,284 Chem.Abstr., 1953 , p. 4325 Full Text Show Details Horowitz; Ullyot Journal of the American Chemical Society, 1952 , vol. 74, p. 587,591

Precursor 2
CAS#:64-86-8 Colchicine CAS#:7664-41-7 Ammonia
DownStream 0

Colchicine amide

Colchicein-amid

Colchicamide

Colchiceinamide

Colchicamide (VAN)

(S)--7-Acetylamino-10-amino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on

N-((S)-10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

14-Aminocolchicide

10-demethoxy-10-N-aminocolchicine

Colchicamid

SKF 3192

Colchicenamide

Colchicide,14-amino

N-((S)-10-Amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid

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Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.