WR99210 hydrochloride

Modify Date: 2024-09-17 15:04:26

WR99210 hydrochloride structure	Common Name	WR99210 hydrochloride
	CAS Number	30711-93-4	Molecular Weight	431.14
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₉Cl₄N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WR99210 hydrochloride

WR99210 hydrochloride is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 hydrochloride shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains as well as T. gondii[1][2][3].

Name	1,3,5-Triazine-2,4-diamine,1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-, hydrochloride(1:1)

Description	WR99210 hydrochloride is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 hydrochloride shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains as well as T. gondii[1][2][3].
Related Catalog	Research Areas >> Infection
References	[1]. Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. [2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41. [3]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8.

Description

Related Catalog

Research Areas >> Infection

References

[1]. Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7.

[2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.

[3]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8.

Molecular Formula	C₁₄H₁₉Cl₄N₅O₂
Molecular Weight	431.14
InChIKey	VOTSDCGUYAGUNS-UHFFFAOYSA-N
SMILES	CC1(C)N=C(N)N=C(N)N1OCCCOc1cc(Cl)c(Cl)cc1Cl.Cl

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: WR-99210
Price: Check
Purity: 99.96%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

WR99210 hydrochloride suppliers

WR99210 hydrochloride price

WR99210 hydrochloride

Use of WR99210 hydrochloride

Names

WR99210 hydrochloride Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.