KL201
Modify Date: 2025-09-19 18:18:23
KL201 structure
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Common Name | KL201 | ||
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| CAS Number | 302939-48-6 | Molecular Weight | 388.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H14BrN3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KL201KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. |
| Name | KL201 |
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| Description | KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. |
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| Related Catalog | |
| In Vitro | KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc, without affecting cellular viability[1]. KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3[1]. KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants[1]. |
| References |
| Molecular Formula | C17H14BrN3OS |
|---|---|
| Molecular Weight | 388.28 |
| InChIKey | KFSLRFWIPVMBNT-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ncnc2sc3c(c12)CCCC3)c1ccccc1Br |