OB-1
Modify Date: 2025-08-22 18:24:07
OB-1 structure
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Common Name | OB-1 | ||
|---|---|---|---|---|
| CAS Number | 300803-69-4 | Molecular Weight | 407.376 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 628.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H17N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 333.9±31.5 °C | |
Use of OB-1A small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo; also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity. |
| Name | Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate |
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| Synonym | More Synonyms |
| Description | A small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo; also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity. |
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| References | References 1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 628.5±55.0 °C at 760 mmHg |
| Molecular Formula | C21H17N3O6 |
| Molecular Weight | 407.376 |
| Flash Point | 333.9±31.5 °C |
| Exact Mass | 407.111725 |
| LogP | 5.15 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.649 |
| MFCD01462999 |
| 3-Benzofurancarboxylic acid, 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-, ethyl ester |
| Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate |