ACBI3

Modify Date: 2025-08-25 19:18:03

ACBI3 Structure
ACBI3 structure
Common Name ACBI3
CAS Number 2938169-76-5 Molecular Weight 1019.25
Density N/A Boiling Point N/A
Molecular Formula C50H62N14O6S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACBI3


ACBI3 (compound 7) is a pan-KRAS degrader. ACBI3 achieves in vivo degradation of oncogenic KRAS[1].

 Names

Name ACBI3

 ACBI3 Biological Activity

Description ACBI3 (compound 7) is a pan-KRAS degrader. ACBI3 achieves in vivo degradation of oncogenic KRAS[1].
Related Catalog
References

[1]. Chuan Zhou, et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022, 65, 5.  

 Chemical & Physical Properties

Molecular Formula C50H62N14O6S2
Molecular Weight 1019.25
InChIKey DQRZNYPHOWVXPQ-YDUPODKQSA-N
SMILES Cc1ncsc1-c1ccc(C(CO)NC(=O)C2CC(O)CN2C(=O)C(C(C)C)n2cc(OCCCCN3CCCN(c4nccc(-c5noc(C6(C)CCCc7sc(N)c(C#N)c76)n5)n4)C(C)C3)nn2)cc1
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