TRK-IN-24
Modify Date: 2024-01-02 14:44:10
TRK-IN-24 structure
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Common Name | TRK-IN-24 | ||
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| CAS Number | 2937544-01-7 | Molecular Weight | 659.82 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H45N7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TRK-IN-24TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA, TRKC, TRKAG595R, TRKAG667C and TRKAF589L IC50s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1G595R and BaF3-CD74-NTRK1G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC50 of 1.43-47.56 nM[1]. |
| Name | TRK-IN-24 |
|---|
| Description | TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA, TRKC, TRKAG595R, TRKAG667C and TRKAF589L IC50s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1G595R and BaF3-CD74-NTRK1G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC50 of 1.43-47.56 nM[1]. |
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| Related Catalog | |
| Target |
IC50: 5.21 nM (TRKA), 4.51 nM (TRKC), 6.77 nM (TRKAG595R), 1.42 nM (TRKAG667C), 6.13 nM (TRKAF589L)[1] |
| References |
| Molecular Formula | C39H45N7O3 |
|---|---|
| Molecular Weight | 659.82 |