Estrogen receptor antagonist 8

Modify Date: 2024-01-02 14:46:17

Estrogen receptor antagonist 8 structure	Common Name	Estrogen receptor antagonist 8
	CAS Number	2889370-92-5	Molecular Weight	427.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₁N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Estrogen receptor antagonist 8

Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo?anti-uterotrophic potential (EC50?=?4.160?μM)[1].

Name	Estrogen receptor antagonist 8

Description	Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo?anti-uterotrophic potential (EC50?=?4.160?μM)[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Metabolic Disease
Target	Estrogen receptor
In Vivo	在体内抗子宫营养试验中，通过测量未成熟雌性大鼠子宫重量与对照组相比的减少，建立了剂量-反应曲线。 Estrogen receptor antagonist 8 (compound 4) (s.c.; 1、3、10、20、30 mg/Kg/天; 3 d) 表现出比 TMX 更好的抗子宫萎缩潜能 (EC50: 7.625 μM), Estrogen receptor antagonist 8 的 EC50 值为 4.160 μM[1]。
References	[1]. Mahmoud A Ragab, et al. Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity. Bioorg Chem. 2022 Feb;119:105554.

Molecular Formula	C₂₅H₂₁N₃O₄
Molecular Weight	427.45

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