Y-320
Modify Date: 2025-08-21 19:19:06
Y-320 structure
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Common Name | Y-320 | ||
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| CAS Number | 288250-47-5 | Molecular Weight | 505.011 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 631.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H29ClN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 335.6±31.5 °C | |
Use of Y-320Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.IC50 value: 20-60 nM (IL-17 production) [1]Target: IL-17Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1]. |
| Name | 1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide |
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| Synonym | More Synonyms |
| Description | Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.IC50 value: 20-60 nM (IL-17 production) [1]Target: IL-17Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 631.2±55.0 °C at 760 mmHg |
| Molecular Formula | C27H29ClN6O2 |
| Molecular Weight | 505.011 |
| Flash Point | 335.6±31.5 °C |
| Exact Mass | 504.204041 |
| PSA | 86.42000 |
| LogP | 3.58 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.675 |
| InChIKey | BWZNJVZTAWBIFG-UHFFFAOYSA-N |
| SMILES | Cc1c(C(=O)Nc2ccc(N3CCC(N4CCOCC4)CC3)c(C#N)c2)cnn1-c1ccc(Cl)cc1 |
| Storage condition | -20℃ |
| 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl- |
| 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide |
| 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide |
| Y320 |
| Y-320 |