CFT1946

Modify Date: 2025-08-26 09:25:10

CFT1946 Structure
CFT1946 structure
Common Name CFT1946
CAS Number 2882165-79-7 Molecular Weight 958.00
Density N/A Boiling Point N/A
Molecular Formula C45H49F2N11O9S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CFT1946


CFT1946 is an orally active and selective target ligand for BRAF kinase. CFT1946 is a degrader of mutant BRAFV600E, G469A, G466V and p61-BRAFV600E. CFT1946 can be used in tumor research[1].

 Names

Name CFT1946

 CFT1946 Biological Activity

Description CFT1946 is an orally active and selective target ligand for BRAF kinase. CFT1946 is a degrader of mutant BRAFV600E, G469A, G466V and p61-BRAFV600E. CFT1946 can be used in tumor research[1].
Related Catalog
References

[1]. Sowa M E, et al. Preclinical evaluation of CFT1946 as a selective degrader of mutant BRAF for the treatment of BRAF driven cancers[J]. Cancer Research, 2022, 82(12_Supplement): 2158-2158.

 Chemical & Physical Properties

Molecular Formula C45H49F2N11O9S
Molecular Weight 958.00
InChIKey OCDRMYDQTIPVOI-HHHXNRCGSA-N
SMILES CCN(C)S(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C4COC5(CCN(C(=O)CC6(O)CCN(c7cc8c(cc7F)c(N7CCC(=O)NC7=O)nn8C)CC6)CC5)C4)c(=O)c3c2)c1C#N
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