GBD-9

Modify Date: 2025-08-25 19:59:02

GBD-9 Structure
GBD-9 structure
 Common Name GBD-9
CAS Number 2864408-92-2 Molecular Weight 797.90
Density N/A Boiling Point N/A
Molecular Formula C44H47N9O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GBD-9


GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].

 Names

Name GBD-9

 GBD-9 Biological Activity

Description GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].
Related Catalog
Target

Cereblon

References

[1]. Zimo Yang, et al. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Res. 2021 Dec;31(12):1315-1318.  

 Chemical & Physical Properties

Molecular Formula C44H47N9O6
Molecular Weight 797.90
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Chemsrc provides GBD-9(CAS#:2864408-92-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of GBD-9 are included as well.>> amp version: GBD-9

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