MRT-2359
Modify Date: 2025-09-03 12:36:39
MRT-2359 structure
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Common Name | MRT-2359 | ||
|---|---|---|---|---|
| CAS Number | 2803881-11-8 | Molecular Weight | 495.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H17F4N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRT-2359MRT-2359 is an orally active and potent degrader of GSPT1 with anti-tumor activity. MRT-2359 also inhibits the growth of resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDXs)[1]. |
| Name | MRT-2359 |
|---|
| Description | MRT-2359 is an orally active and potent degrader of GSPT1 with anti-tumor activity. MRT-2359 also inhibits the growth of resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDXs)[1]. |
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| Related Catalog | |
| Target |
GSPT1[1] |
| References |
| Molecular Formula | C22H17F4N3O6 |
|---|---|
| Molecular Weight | 495.38 |
| InChIKey | HNTGMIGBGVFOBT-UHFFFAOYSA-N |
| SMILES | O=C1CCC(N2Cc3ccc(COC(=O)Nc4cc(OC(F)(F)F)ccc4F)cc3C2=O)C(=O)N1 |