STAT3-IN-20

Modify Date: 2025-08-26 16:38:37

STAT3-IN-20 structure	Common Name	STAT3-IN-20
	CAS Number	2768427-54-7	Molecular Weight	593.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₂₇F₄N₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of STAT3-IN-20

STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis[1].

Name	STAT3-IN-20

Description	STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	0.65 μM (STAT3)[1]
References	[1]. Wang R, et al. Discovery, Optimization, and Evaluation of Novel N-(Benzimidazol-5-yl)-1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment. J Med Chem. 2023 Aug 18.

Molecular Formula	C₃₀H₂₇F₄N₇S
Molecular Weight	593.64
InChIKey	OOARMSSXPHSBDL-UHFFFAOYSA-N
SMILES	CN1CCN(c2cc3c(cc2Nc2nnc(-c4ccc(C(F)(F)F)cc4)s2)nc(-c2ccc(F)cc2)n3C2CC2)CC1

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STAT3-IN-20

Use of STAT3-IN-20

Names

STAT3-IN-20 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.