Tutuilamide A

Modify Date: 2025-08-25 12:17:52

Tutuilamide A structure	Common Name	Tutuilamide A
	CAS Number	2756129-42-5	Molecular Weight	1021.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₁H₆₉ClN₈O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tutuilamide A

Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM)[1].

Name	Tutuilamide A

Description	Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Research Areas >> Inflammation/Immunology
Target	IC50: 1.2 nM (porcine pancreatic elastase), 0.73 nM (human neutrophil elastase), 5.0 nM (kallikrein 7)[1]
References	[1]. Chen QY, et, al. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7. Bioorg Med Chem. 2020 Dec 1;28(23):115756.

Molecular Formula	C₅₁H₆₉ClN₈O₁₂
Molecular Weight	1021.59

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