Thalidomide-5-PEG4-NH2 hydrochloride

Modify Date: 2025-08-27 18:11:38

Thalidomide-5-PEG4-NH2 hydrochloride Structure
Thalidomide-5-PEG4-NH2 hydrochloride structure
 Common Name Thalidomide-5-PEG4-NH2 hydrochloride
CAS Number 2743434-24-2 Molecular Weight 485.92
Density N/A Boiling Point N/A
Molecular Formula C21H28ClN3O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-5-PEG4-NH2 hydrochloride


Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

 Names

Name Thalidomide-5-PEG4-NH2 hydrochloride

 Thalidomide-5-PEG4-NH2 hydrochloride Biological Activity

Description Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.  

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.  

 Chemical & Physical Properties

Molecular Formula C21H28ClN3O8
Molecular Weight 485.92
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