STING agonist-31
Modify Date: 2025-09-14 11:34:32
STING agonist-31 structure
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Common Name | STING agonist-31 | ||
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| CAS Number | 2719001-44-0 | Molecular Weight | 873.96 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C43H51N15O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STING agonist-31STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1]. |
| Name | STING agonist-31 |
|---|
| Description | STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1]. |
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| Related Catalog | |
| In Vitro | STING agonist-31 (化合物 40) 激活 h-STING 和 m-STING，EC50 值为 0.24 和 39.51 μM[1]。 STING agonist-31 (0-10 μM，24 h) 激活 ISG 信号和 NF-κB 信号[1]。 |
| In Vivo | STING agonist-31 (化合物 40) (10 mg/kg，静脉注射) 抑制 4T1 和 CT26 小鼠肿瘤模型中的肿瘤生长[1]。 STING agonist-31 (1 mg/kg，静脉注射) 在大鼠中显示出 T1/2：0.697 h，AUClast 678 h•ng/mL[1]< /sup>. Animal Model: Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1] Dosage: 10 mg/kg Administration: i.v., at days 1, 4, and 7 Result: Inhibited tumor Growth. |
| References |
| Molecular Formula | C43H51N15O6 |
|---|---|
| Molecular Weight | 873.96 |
| InChIKey | RZBQZKAZIZWIRZ-CMDGGOBGSA-N |
| SMILES | CCn1nc(C)cc1C(=O)Nc1nc2cc(-c3ncn[nH]3)cc(OC)c2n1CC=CCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(C(N)=O)cc(OCCCN3CCOCC3)c21 |