5-Methoxyquinazoline-2,4-diamine

Modify Date: 2024-01-05 16:53:44

5-Methoxyquinazoline-2,4-diamine Structure
5-Methoxyquinazoline-2,4-diamine structure
Common Name 5-Methoxyquinazoline-2,4-diamine
CAS Number 27018-21-9 Molecular Weight 190.20200
Density 1.372g/cm3 Boiling Point 484.8ºC at 760mmHg
Molecular Formula C9H10N4O Melting Point N/A
MSDS N/A Flash Point 247ºC

 Names

Name 5-Methoxy-quinazoline-2,4-diamine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.372g/cm3
Boiling Point 484.8ºC at 760mmHg
Molecular Formula C9H10N4O
Molecular Weight 190.20200
Flash Point 247ºC
Exact Mass 190.08500
PSA 87.05000
LogP 1.96520
Vapour Pressure 1.49E-09mmHg at 25°C
Index of Refraction 1.732

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA1367800
CHEMICAL NAME :
2,4-Quinazolinediamine, 5-methoxy-
CAS REGISTRY NUMBER :
27018-21-9
BEILSTEIN REFERENCE NO. :
0746085
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H10-N4-O
MOLECULAR WEIGHT :
190.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,434,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
137 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,434,1990

 Safety Information

HS Code 2933990090

 Synthetic Route

~71%

5-Methoxyquinazoline-2,4-diamine Structure

5-Methoxyquinaz...

CAS#:27018-21-9

Literature: Shanghai Institute Materia Medica, Chinese Academy Of Sciences; ZUO, Jianping; HU, Youhong; TANG, Wei; CHAO, Bo; TONG, Xiankun; LI, Dewen; JI, Feihong; HE, Peilan Patent: EP2649999 A1, 2013 ; Location in patent: Paragraph 0023 ;

~92%

5-Methoxyquinazoline-2,4-diamine Structure

5-Methoxyquinaz...

CAS#:27018-21-9

Literature: Hynes, John B.; Pathak, Alpana; Panos, Constantina H.; Okeke, Claudia C. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1173 - 1177

~40%

5-Methoxyquinazoline-2,4-diamine Structure

5-Methoxyquinaz...

CAS#:27018-21-9

Literature: Thurmond, John; Butchbach, Matthew E. R.; Palomo, Marty; Pease, Brian; Rao, Munagala; Bedell, Louis; Keyvan, Monica; Pai, Grace; Mishra, Rama; Haraldsson, Magnus; Andresson, Thorkell; Bragason, Gisli; Thosteinsdottir, Margret; Bjornsson, Jon Mar; Coovert, Daniel D.; Burghes, Arthur H. M.; Gurney, Mark E.; Singh, Jasbir Journal of Medicinal Chemistry, 2008 , vol. 51, # 3 p. 449 - 469

~%

5-Methoxyquinazoline-2,4-diamine Structure

5-Methoxyquinaz...

CAS#:27018-21-9

Literature: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; Zuo, Jianping; Hu, Youhong; Tang, Wei; Chao, Bo; Tong, Xiankun; Li, Dewen; Ji, Feihong; He, Peilan Patent: US2013/261139 A1, 2013 ;

~%

5-Methoxyquinazoline-2,4-diamine Structure

5-Methoxyquinaz...

CAS#:27018-21-9

Literature: Nelson; Rosowsky Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 12 p. 3293 - 3303

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

5-methoxyquinazoline-2,4-diamine
2,4-diamino-5-methoxyquinazoline
2,4-Quinazolinediamine,5-methoxy
5-Methoxy-2,4-chinazolindiamin
5-Methoxy-2,4-diaminoquinazoline