KRAS G12D inhibitor 16

Modify Date: 2024-04-07 00:03:50

KRAS G12D inhibitor 16 Structure
KRAS G12D inhibitor 16 structure
Common Name KRAS G12D inhibitor 16
CAS Number 2648221-12-7 Molecular Weight 682.59
Density N/A Boiling Point N/A
Molecular Formula C32H39IN6O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KRAS G12D inhibitor 16


KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].

 Names

Name KRAS G12D inhibitor 16

 KRAS G12D inhibitor 16 Biological Activity

Description KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].
Related Catalog
Target

KRas G12D:0.7 nM (IC50)

In Vitro KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC50 value of 0.7 nM[1]. KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC50 value of 0.35 μM[1].
References

[1]. Yuichi Kawai, et al. A compound having inhibitory activity against kras g12d mutation. Patent. WO2021107160A1.

 Chemical & Physical Properties

Molecular Formula C32H39IN6O3
Molecular Weight 682.59