GSK3987
Modify Date: 2024-01-03 11:13:45
GSK3987 structure
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Common Name | GSK3987 | ||
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| CAS Number | 264206-85-1 | Molecular Weight | 384.427 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 572.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H20N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 299.9±30.1 °C | |
Use of GSK3987GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation[1]. |
| Name | GSK3987 |
|---|---|
| Synonym | More Synonyms |
| Description | GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation[1]. |
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| Related Catalog | |
| Target |
EC50: 50 nM (LXRα); 40 nM (LXRβ)[1] |
| In Vitro | GSK3987 (compound 4) shows activity with EC50s of 0.08 µM, 50 nM, 40 nM for ABCA1, LXRα-SRC1, LXRβ-SRC1, respectively[1]. GSK3987 (30, 100, 300, 1000 nM) increases the expression of ABCA1 and induces cellular cholesterol efflux to apoA1 particles in a dose-dependent manner in primary human macrophages[1]. GSK3987 (6-1500 nM) increases the expression of SREBP-1c and induces triglyceride accumulation in human hepatoma (HepG2) cells in a dose-dependent manner[1]. RT-PCR[1] Cell Line: HepG2 cells Concentration: 6-1500 nM Incubation Time: Result: Increased the expression of SREBP-1c and induced triglyceride accumulation in human hepatoma (HepG2) cells in a dose-dependent manner. |
| References |
[1]. HepG2 cells, ABCA1, SREBP-1c, cellular cholesterol, macrophages, triglyceride accumulation |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 572.4±50.0 °C at 760 mmHg |
| Molecular Formula | C24H20N2O3 |
| Molecular Weight | 384.427 |
| Flash Point | 299.9±30.1 °C |
| Exact Mass | 384.147400 |
| LogP | 4.35 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.684 |
| Storage condition | 2-8°C |
| 1-Benzyl-3-[(4-methoxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione |
| 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE |
| 1H-Pyrrole-2,5-dione, 3-[(4-methoxyphenyl)amino]-4-phenyl-1-(phenylmethyl)- |