CDK5-IN-2

Modify Date: 2025-08-25 09:21:23

CDK5-IN-2 Structure
CDK5-IN-2 structure
Common Name CDK5-IN-2
CAS Number 2639542-22-4 Molecular Weight 481.56
Density N/A Boiling Point N/A
Molecular Formula C29H28FN5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CDK5-IN-2


CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].

 Names

Name CDK5-IN-2

 CDK5-IN-2 Biological Activity

Description CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].
Related Catalog
Target

Cdk5/p25:0.2 nM (IC50)

CDK2/CycA:23 nM (IC50)

References

[1]. Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596.

 Chemical & Physical Properties

Molecular Formula C29H28FN5O
Molecular Weight 481.56
InChIKey KKNXJZMTIWJEEF-GDLZYMKVSA-N
SMILES CN1CCC(C(C)(O)c2ccc3cnc(Nc4ccc(-c5cccc(C#N)c5)cc4F)cc3n2)CC1
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