(9Z)-12,13-Dihydroxy-9-octadecenoic acid

Modify Date: 2024-01-09 11:04:31

(9Z)-12,13-Dihydroxy-9-octadecenoic acid structure	Common Name	(9Z)-12,13-Dihydroxy-9-octadecenoic acid
	CAS Number	263399-35-5	Molecular Weight	314.46
	Density	1.0±0.1 g/cm3	Boiling Point	476.0±30.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₃₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	255.8±21.1 °C

Use of (9Z)-12,13-Dihydroxy-9-octadecenoic acid

12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders[1].

Name	(±)12,13-DiHOME
Synonym	More Synonyms

Description	12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders[1].
Related Catalog	Research Areas >> Metabolic Disease
In Vivo	12,13-DiHOME (1 μg/kg；眼球后注射；每天 1 次，共 2 周) 能显著降低小鼠高脂饮食模型中血清甘油三酯水平，并增加 BAT 的摄取以抵御寒冷[1]。 Animal Model: Mice fed a high-fat diet[1] Dosage: 1 μg/kg Administration: Retro-orbitally injection; once daily for 2 weeks Result: Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA. Increased BAT-specific lipid uptake and improved oral lipid tolerance. Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake. Animal Model: To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1] Dosage: Administration: 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h Result: Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.
References	[1]. Lynes MD, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May;23(5):631-637.

Density	1.0±0.1 g/cm3
Boiling Point	476.0±30.0 °C at 760 mmHg
Molecular Formula	C₁₈H₃₄O₄
Molecular Weight	314.46
Flash Point	255.8±21.1 °C
Exact Mass	314.245697
PSA	77.76000
LogP	4.14
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.493