ARD-2051

Modify Date: 2025-08-26 19:00:40

ARD-2051 Structure
ARD-2051 structure
Common Name ARD-2051
CAS Number 2632305-17-8 Molecular Weight 789.32
Density N/A Boiling Point N/A
Molecular Formula C43H45ClN8O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ARD-2051


ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 can be used for the research of prostate cancer[1].

 Names

Name ARD-2051

 ARD-2051 Biological Activity

Description ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 can be used for the research of prostate cancer[1].
Related Catalog
Target

DC50: 0.6 nM (AR protein degradation)[1]

References

[1]. Han X, et al. Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2023 Jul 13;66(13):8822-8843.  

 Chemical & Physical Properties

Molecular Formula C43H45ClN8O5
Molecular Weight 789.32
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