ART812
Modify Date: 2025-08-25 08:58:53
ART812 structure
|
Common Name | ART812 | ||
|---|---|---|---|---|
| CAS Number | 2607138-82-7 | Molecular Weight | 461.79 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H16ClF4N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ART812ART812 is a DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2]. |
| Name | ART812 |
|---|
| Description | ART812 is a DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Polθ:7.6 nM (IC50) |
| In Vitro | ART812 (0-40 μM) elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells[1]. |
| In Vivo | ART812 (100 mg/kg; p.o. daily for 76 days) shows significant tumour inhibition in rats bearing established MDA-MB-436 BRCA1/SHLD2 defective tumours (volume 250-350 mm3)[1]. |
| References |
| Molecular Formula | C19H16ClF4N3O4 |
|---|---|
| Molecular Weight | 461.79 |
| InChIKey | YJJOABOMFPGRED-JYJNAYRXSA-N |
| SMILES | Cc1cc(C(F)(F)F)cc(N2C(=O)C(O)C(O)C2C(=O)N(C)c2ccc(F)c(Cl)c2)n1 |