PROTAC BRD4 Degrader-17
Modify Date: 2025-09-05 21:06:45
PROTAC BRD4 Degrader-17 structure
|
Common Name | PROTAC BRD4 Degrader-17 | ||
|---|---|---|---|---|
| CAS Number | 2585561-49-3 | Molecular Weight | 877.94 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C49H47N7O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC BRD4 Degrader-17PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells[1]. |
| Name | PROTAC BRD4 Degrader-17 |
|---|
| Description | PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells[1]. |
|---|---|
| Related Catalog | |
| Target |
BRD4 (BD2):3.82 ± 0.0 nM (IC50) BRD4 (BD1):29.54 ± 2. nM (IC50) |
| In Vitro | PROTAC BRD4 Degrader-17 (compound 13i) (100 nM，4-24 h) 在MV-4-11细胞中 4 h以 100 nM 的浓度显着诱导 BRD4 L 和 BRD4 S 降解，然后像 dBET6 一样在 24 h 恢复 BRD4 S[1]。 |
| References |
| Molecular Formula | C49H47N7O9 |
|---|---|
| Molecular Weight | 877.94 |
| InChIKey | HBAAAVQUHXUWNR-UHFFFAOYSA-N |
| SMILES | Cn1cc(-c2cc(C(C)(C)O)ccc2Oc2ccccc2)c2cc(C(=O)NCc3ccc(C(=O)NCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)[nH]c2c1=O |