CU-CPD107
Modify Date: 2025-08-27 18:14:56
CU-CPD107 structure
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Common Name | CU-CPD107 | ||
|---|---|---|---|---|
| CAS Number | 2573912-32-8 | Molecular Weight | 400.26 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H21In2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CU-CPD107CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA.CU-CPD107 significantly inhibited of R848-induced signaling in HEK-Blue hTLR8 cells with an IC50 of 13.7 uM.CU-CPD107 only inhibited synthesized small-molecule agonist-induced TLR8 signaling without affecting other TLRs.CU-CPD107 synergistically increased IFN-β, TNF-α, IL-1β, IL-6, and IL-8 mRNA expression levels in the presence of 5 μg/ml ssRNA40 in HEK-Blue hTLR8 cells, whereas CU-CPD107 alone did not. CU-CPD107 only activated TLR8-mediated signaling in the presence of ssRNA.CU-CPD107 showed no pure agonistic activity, addressing a major challenge that has existed for previous TLR7 and TLR8 agonists as vaccine adjuvants or antiviral drugs. |
| Name | CU-CPD107 |
|---|
| Description | CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA.CU-CPD107 significantly inhibited of R848-induced signaling in HEK-Blue hTLR8 cells with an IC50 of 13.7 uM.CU-CPD107 only inhibited synthesized small-molecule agonist-induced TLR8 signaling without affecting other TLRs.CU-CPD107 synergistically increased IFN-β, TNF-α, IL-1β, IL-6, and IL-8 mRNA expression levels in the presence of 5 μg/ml ssRNA40 in HEK-Blue hTLR8 cells, whereas CU-CPD107 alone did not. CU-CPD107 only activated TLR8-mediated signaling in the presence of ssRNA.CU-CPD107 showed no pure agonistic activity, addressing a major challenge that has existed for previous TLR7 and TLR8 agonists as vaccine adjuvants or antiviral drugs. |
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| References | 1. Yi Yang, et al. Nat Commun. 2021 Jul 16;12(1):4351. |
| Molecular Formula | C16H21In2O2 |
|---|---|
| Molecular Weight | 400.26 |
| InChIKey | XCYMSVIYUJTAPJ-UHFFFAOYSA-N |
| SMILES | CCOCc1nc(I)c(-c2ccccc2)n1CC(C)(C)O |