Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt

Modify Date: 2024-01-05 11:11:40

Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt structure	Common Name	Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt
	CAS Number	256447-08-2	Molecular Weight	1351.57000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₃H₉₄N₁₄O₁₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt

Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].

Name	Ac2-12
Synonym	More Synonyms

Description	Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)[1]. Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice[2].
References	[1]. L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14535-9. [2]. M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73.

Molecular Formula	C₆₃H₉₄N₁₄O₁₇S
Molecular Weight	1351.57000
Exact Mass	1350.66000
PSA	525.13000
LogP	3.83750

AC-ALA-MET-VAL-SER-GLU-PHE-LEU-LYS-GLN-ALA-TRP-OH

ANXA-1

ANNEXIN 1

AC-AMVSEFLKQAW

Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp

GL Biochem (Shanghai) Ltd.
China
Product Name: Ac-AMVSEFLKQAW
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

DC Chemicals Limited
China
Product Name: Ac2-12
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Nanjing Peptide Biotech Ltd
China
Product Name: Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

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