BJJF078

Modify Date: 2024-04-08 16:35:59

BJJF078 Structure
BJJF078 structure
Common Name BJJF078
CAS Number 2531244-56-9 Molecular Weight 523.60
Density N/A Boiling Point N/A
Molecular Formula C27H29N3O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BJJF078


BJJF078 is an aminopiperidine derivative. BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme (TG2) activity, IC50 values of 41 and 54 nM, respectively. BJJF078 also inhibits the close related enzyme TG1, with an IC50 of 0.16 μM. BJJF078 can be used for Multiple sclerosis (MS) research[1].

 Names

Name BJJF078

 BJJF078 Biological Activity

Description BJJF078 is an aminopiperidine derivative. BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme (TG2) activity, IC50 values of 41 and 54 nM, respectively. BJJF078 also inhibits the close related enzyme TG1, with an IC50 of 0.16 μM. BJJF078 can be used for Multiple sclerosis (MS) research[1].
Related Catalog
Target

IC50: 41 nM (hTG2), 54 nM (mTG2), 0.16 μM (TG1)[1]

References

[1]. Chrobok NL, et al. Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis. PLoS One. 2018 Apr 24;13(4):e0196433.  

 Chemical & Physical Properties

Molecular Formula C27H29N3O6S
Molecular Weight 523.60
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