TIM-063
Modify Date: 2025-08-25 14:22:52
TIM-063 structure
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Common Name | TIM-063 | ||
|---|---|---|---|---|
| CAS Number | 2493978-38-2 | Molecular Weight | 331.287 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H9N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TIM-063TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells. TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways. |
| Name | TIM-063 |
|---|
| Description | TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells. TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways. |
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| References | 1. Ohtsuka S, et al. Biochemistry. 2020 May 5;59(17):1701-1710. 2. Satomi Ohtsuka, et al. Biochemistry, March 11, 2022. 3. Toshio Kitazawa, et al. Am J Physiol Cell Physiol. 2021 Sep 1;321(3):C549-C558. |
| Molecular Formula | C18H9N3O4 |
|---|---|
| Molecular Weight | 331.287 |
| InChIKey | RDNQPAWXXJDVPO-UHFFFAOYSA-N |
| SMILES | O=c1c2cccc3c([N+](=O)[O-])c(O)cc(c32)c2nc3ccccc3n12 |