tetranor-PGEM (tetranor-Prostaglandin E Metabolite)

Modify Date: 2024-01-04 12:45:29

tetranor-PGEM (tetranor-Prostaglandin E Metabolite) Structure
tetranor-PGEM (tetranor-Prostaglandin E Metabolite) structure
Common Name tetranor-PGEM (tetranor-Prostaglandin E Metabolite)
CAS Number 24769-56-0 Molecular Weight 328.358
Density 1.3±0.1 g/cm3 Boiling Point 622.4±55.0 °C at 760 mmHg
Molecular Formula C16H24O7 Melting Point N/A
MSDS N/A Flash Point 344.2±28.0 °C

 Use of tetranor-PGEM (tetranor-Prostaglandin E Metabolite)


PGE-M is a metabolite of prostaglandin E2 (PEG2) as a biomarker of inflammation and cancer including advanced colorectal neoplasia, ovarian cancer, prostate cancer and so on. Urinary PGE-M is positively associated with obesity, smoking and lung metastases with breast cancer[1][2][3].

 Names

Name 9,15-dioxo-11alpha-hydroxy-2,3,4,5-tetranor-prostan-1,20-dioic acid
Synonym More Synonyms

  Biological Activity

Description PGE-M is a metabolite of prostaglandin E2 (PEG2) as a biomarker of inflammation and cancer including advanced colorectal neoplasia, ovarian cancer, prostate cancer and so on. Urinary PGE-M is positively associated with obesity, smoking and lung metastases with breast cancer[1][2][3].
Related Catalog
References

[1]. Johnson JC, et al. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol. 2006 Nov;4(11):1358-65.

[2]. Wang D, DuBois RN. Urinary PGE-M: a promising cancer biomarker. Cancer Prev Res (Phila). 2013 Jun;6(6):507-10.

[3]. Morris PG, et al. Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer. Cancer Prev Res (Phila). 2013 May;6(5):428-36.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 622.4±55.0 °C at 760 mmHg
Molecular Formula C16H24O7
Molecular Weight 328.358
Flash Point 344.2±28.0 °C
Exact Mass 328.152191
PSA 128.97000
LogP -0.90
Vapour Pressure 0.0±4.1 mmHg at 25°C
Index of Refraction 1.529

 Safety Information

HS Code 2918990090

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

8-[(1R,2R,5R)-2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-6-oxooctanoic acid
Cyclopentaneoctanoic acid, 2-(2-carboxyethyl)-5-hydroxy-η,3-dioxo-, (1R,2R,5R)-
11alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoicacid
8-[(1R,2R,5R)-2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-8-oxooctanoic acid
TETRANOR-PGEM
tetranor-prostaglandin E metabolite
Cyclopentaneoctanoic acid, 2-(2-carboxyethyl)-5-hydroxy-ε,3-dioxo-, (1R,2R,5R)-
tetranor-PGEM Lipid Maps MS Standard
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