NVP DPP 728

Modify Date: 2025-08-24 23:30:24

NVP DPP 728 Structure
NVP DPP 728 structure
 Common Name NVP DPP 728
CAS Number 247016-69-9 Molecular Weight 298.34
Density N/A Boiling Point N/A
Molecular Formula C15H18N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NVP DPP 728


NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].

 Names

Name 6-[2-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile,dihydrochloride
Synonym More Synonyms

 NVP DPP 728 Biological Activity

Description NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].
Related Catalog
Target

Ki: 11 nM (DPP-IV)[1]

References

[1]. Hughes TE, et al. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999;38(36):11597-11603.

 Chemical & Physical Properties

Molecular Formula C15H18N6O
Molecular Weight 298.34
Exact Mass 370.107574
PSA 104.84000
LogP 2.47516
InChIKey VFFZWMWTUSXDCB-UHFFFAOYSA-N
SMILES N#Cc1ccc(NCCNCC(=O)N2CCCC2C#N)nc1

 Synthetic Route

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile structure

(2S)-1-(Chloroa...

CAS#:207557-35-5

6-[(2-AMINOETHYL)AMINO]NICOTINONITRILE structure

6-[(2-AMINOETHY...

CAS#:202460-48-8

~32%

NVP DPP 728 Structure

NVP DPP 728

CAS#:247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Dunning, Beth E.; Mangold, Bonnie L.; Mone, Manisha D.; Russell, Mary E.; Weldon, Stephen C.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2362 - 2365
1-(Chloroacetyl)-L-prolinamide structure

1-(Chloroacetyl...

CAS#:214398-99-9

~%

NVP DPP 728 Structure

NVP DPP 728

CAS#:247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Burkey, Bryan F.; Dunning, Beth E.; Prasad, Kapa; Mangold, Bonnie L.; Russell, Mary E.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2003 , vol. 46, # 13 p. 2774 - 2789
L-Prolinamide structure

L-Prolinamide

CAS#:7531-52-4

~%

NVP DPP 728 Structure

NVP DPP 728

CAS#:247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Burkey, Bryan F.; Dunning, Beth E.; Prasad, Kapa; Mangold, Bonnie L.; Russell, Mary E.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2003 , vol. 46, # 13 p. 2774 - 2789
2-Pyrrolidinecarbonitrile, 1-(bromoacetyl)-, (2S)- (9CI) structure

2-Pyrrolidineca...

CAS#:207557-33-3

~%

NVP DPP 728 Structure

NVP DPP 728

CAS#:247016-69-9

Literature: Willand, Nicolas; Joossens, Jurgen; Gesquiere, Jean-Claude; Tartar, Andre L; Evans, D.Michael; Roe, Michael B Tetrahedron, 2002 , vol. 58, # 28 p. 5741 - 5746
N/A structure

N/A

CAS#:477290-51-0

~%

NVP DPP 728 Structure

NVP DPP 728

CAS#:247016-69-9

Literature: Willand, Nicolas; Joossens, Jurgen; Gesquiere, Jean-Claude; Tartar, Andre L; Evans, D.Michael; Roe, Michael B Tetrahedron, 2002 , vol. 58, # 28 p. 5741 - 5746
(6-Chloro-3-pyridinyl)acetonitrile structure

(6-Chloro-3-pyr...

CAS#:33252-28-7

~%

NVP DPP 728 Structure

NVP DPP 728

CAS#:247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Dunning, Beth E.; Mangold, Bonnie L.; Mone, Manisha D.; Russell, Mary E.; Weldon, Stephen C.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2362 - 2365

 Synonyms

3-Pyridinecarbonitrile, 6-[[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino]-, hydrochloride (1:2)
6-{[2-({2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl}amino)ethyl]amino}nicotinonitrile dihydrochloride
6-{[2-({2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}nicotinonitrile dihydrochloride
nvp dpp 728 dihydrochloride
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