Tetra(cyanoethoxymethyl) methane

Modify Date: 2024-01-02 00:15:55

Tetra(cyanoethoxymethyl) methane Structure
Tetra(cyanoethoxymethyl) methane structure
Common Name Tetra(cyanoethoxymethyl) methane
CAS Number 2465-91-0 Molecular Weight 348.39700
Density 1.13g/cm3 Boiling Point 610.6ºC at 760 mmHg
Molecular Formula C17H24N4O4 Melting Point N/A
MSDS N/A Flash Point 232ºC

 Use of Tetra(cyanoethoxymethyl) methane


Tetra(cyanoethoxymethyl) methane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-[3-(2-cyanoethoxy)-2,2-bis(2-cyanoethoxymethyl)propoxy]propanenitrile
Synonym More Synonyms

 Tetra(cyanoethoxymethyl) methane Biological Activity

Description Tetra(cyanoethoxymethyl) methane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.13g/cm3
Boiling Point 610.6ºC at 760 mmHg
Molecular Formula C17H24N4O4
Molecular Weight 348.39700
Flash Point 232ºC
Exact Mass 348.18000
PSA 132.08000
LogP 1.69392
Vapour Pressure 7.54E-15mmHg at 25°C
Index of Refraction 1.479

 Synthetic Route

~99%

Tetra(cyanoethoxymethyl) methane Structure

Tetra(cyanoetho...

CAS#:2465-91-0

Literature: Lee, Wai Mun Patent: US2009/112024 A1, 2009 ; Location in patent: Page/Page column 18 ;

~97%

Tetra(cyanoethoxymethyl) methane Structure

Tetra(cyanoetho...

CAS#:2465-91-0

Literature: FUJIFILM Corporation Patent: US2009/143623 A1, 2009 ; Location in patent: Page/Page column 4 ;

~%

Tetra(cyanoethoxymethyl) methane Structure

Tetra(cyanoetho...

CAS#:2465-91-0

Literature: Newkome, George R.; Weis, Claus D. Organic Preparations and Procedures International, 1996 , vol. 28, # 2 p. 242 - 244

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

MFCD00053281