PROTAC BRAF-V600E degrader-2

Modify Date: 2024-01-12 09:42:03

PROTAC BRAF-V600E degrader-2 structure	Common Name	PROTAC BRAF-V600E degrader-2
	CAS Number	2417296-82-1	Molecular Weight	839.86
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₂H₃₉F₂N₇O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PROTAC BRAF-V600E degrader-2

PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].

Name	PROTAC BRAF-V600E degrader-2

Description	PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf Signaling Pathways >> PROTAC >> PROTAC
Target	BRAF-V600E:9.5 nM (Kd) Braf:14.4 nM (Kd) Cereblon
References	[1]. Xiao-Ran Han, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. J Med Chem. 2020 Apr 23;63(8):4069-4080.

Molecular Formula	C₄₂H₃₉F₂N₇O₈S
Molecular Weight	839.86

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PROTAC BRAF-V600E degrader-2

Use of PROTAC BRAF-V600E degrader-2

Names

PROTAC BRAF-V600E degrader-2 Biological Activity

Chemical & Physical Properties