HER2-IN-14
Modify Date: 2025-08-24 20:18:58
HER2-IN-14 structure
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Common Name | HER2-IN-14 | ||
|---|---|---|---|---|
| CAS Number | 2414056-35-0 | Molecular Weight | 568.96 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H23ClF2N8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HER2-IN-14HER2-IN-14 (Compound 34) is an HER2 inhibitor with an IC50 of 18 nM. HER2-IN-14 also inhibits wt-EGFR with an IC50 of 6.3 μM[1]. |
| Name | HER2-IN-14 |
|---|
| Description | HER2-IN-14 (Compound 34) is an HER2 inhibitor with an IC50 of 18 nM. HER2-IN-14 also inhibits wt-EGFR with an IC50 of 6.3 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
HER2:18 nM (IC50) EGFR (WT):6.3 μM (IC50) |
| References |
[1]. Ding Zhou, et al. Quinazoline derivatives as antitumor agents. Patent WO2020057511A1. |
| Molecular Formula | C26H23ClF2N8O3 |
|---|---|
| Molecular Weight | 568.96 |
| InChIKey | OCTIIGKPLDEYJH-FQEVSTJZSA-N |
| SMILES | COc1ccc2ncnc(Nc3ccc(Oc4cc5ncnn5cn4)c(Cl)c3)c2c1OC1CCN(C)CC1(F)F |