Thalidomide-5-NH-CH2-COO(t-Bu)
Modify Date: 2024-03-04 19:27:34
Thalidomide-5-NH-CH2-COO(t-Bu) structure
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Common Name | Thalidomide-5-NH-CH2-COO(t-Bu) | ||
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| CAS Number | 2412056-28-9 | Molecular Weight | 387.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Thalidomide-5-NH-CH2-COO(t-Bu)Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
| Name | Thalidomide-5-NH-CH2-COO(t-Bu) |
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| Synonym | More Synonyms |
| Description | Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
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| Related Catalog |
| Molecular Formula | C19H21N3O6 |
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| Molecular Weight | 387.39 |
| Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester |