CWI1-2 hydrochloride
Modify Date: 2025-08-25 14:25:02
CWI1-2 hydrochloride structure
|
Common Name | CWI1-2 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 2408590-37-2 | Molecular Weight | 556.23 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18Cl4N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CWI1-2 hydrochlorideCWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1]. |
| Name | CWI1-2 hydrochloride |
|---|
| Description | CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1]. |
|---|---|
| Related Catalog | |
| In Vitro | CWI1-2 (0-1 μM, 24 h) hydrochloride 具有良好的抗白血病功效[1]。 Apoptosis Analysis[1] Cell Line: MonoMac6, MOLM13 Concentration: 0-1 μM Incubation Time: 24 h Result: Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC. |
| In Vivo | CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）hydrochloride 可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响 [1]。 |
| References |
| Molecular Formula | C22H18Cl4N6O3 |
|---|---|
| Molecular Weight | 556.23 |
| InChIKey | UXAOLDYLYMMMRC-SXOKSYETSA-N |
| SMILES | Cl.Oc1ccc(Cl)cc1C=NN=C(NN=Cc1cc(Cl)ccc1O)NN=Cc1cc(Cl)ccc1O |