M2N12

Modify Date: 2025-08-27 21:07:19

M2N12 Structure
M2N12 structure
Common Name M2N12
CAS Number 2376577-06-7 Molecular Weight 393.83
Density N/A Boiling Point N/A
Molecular Formula C20H16ClN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of M2N12


M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity[1].

 Names

Name M2N12

 M2N12 Biological Activity

Description M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09  μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity[1].
Related Catalog
In Vitro M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively)[1].
References

[1]. Jing L, et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem. 2019 Sep 14;183:111696.

 Chemical & Physical Properties

Molecular Formula C20H16ClN5O2
Molecular Weight 393.83
InChIKey BDBIMDYALUJAPR-UHFFFAOYSA-N
SMILES Cc1ccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)cc1
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