Norethindrone-d6

Modify Date: 2024-04-02 11:34:57

Norethindrone-d6 structure	Common Name	Norethindrone-d6
	CAS Number	2376036-05-2	Molecular Weight	304.46
	Density	1.2±0.1 g/cm3	Boiling Point	447.0±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀D₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	190.5±21.3 °C

Use of Norethindrone-d6

Norethindrone-d6 is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

Name	Norethindrone-d6
Synonym	More Synonyms

Description	Norethindrone-d6 is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7. [3]. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8. [4]. Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. [5]. Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46(1):41-8.

Density	1.2±0.1 g/cm3
Boiling Point	447.0±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀D₆O₂
Molecular Weight	304.46
Flash Point	190.5±21.3 °C
Exact Mass	304.230927
LogP	3.38
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.577
Storage condition	-20°C

Estr-4-en-3-one-2,2,4,6,6,10-d6, 17-ethynyl-17-hydroxy-, (17β)-

(17α)-17-Hydroxy(2,2,4,6,6,10-2H6)-19-norpregn-4-en-20-yn-3-one

Norethindrone-d6

Use of Norethindrone-d6

Names

Norethindrone-d6 Biological Activity

Chemical & Physical Properties

Synonyms