7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one

Modify Date: 2025-09-01 17:51:45

7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one structure	Common Name	7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one
	CAS Number	23749-58-8	Molecular Weight	270.28
	Density	1.4g/cm3	Boiling Point	613.6ºC at 760mmHg
	Molecular Formula	C₁₈H₁₀N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	324.9ºC

Use of 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

Name	Yellow-green 490RT
Synonym	More Synonyms

Description	AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
References	[1]. Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042.

Density	1.4g/cm3
Boiling Point	613.6ºC at 760mmHg
Molecular Formula	C₁₈H₁₀N₂O
Molecular Weight	270.28
Flash Point	324.9ºC
Exact Mass	270.07900
PSA	34.37000
LogP	3.59190
Vapour Pressure	5.41E-15mmHg at 25°C
Index of Refraction	1.777

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD5380000

CHEMICAL NAME :: 7H-Benzimidazo(2,1-a)benz(de)isoquinolin-7-one

CAS REGISTRY NUMBER :: 23749-58-8

BEILSTEIN REFERENCE NO. :: 0243687

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H10-N2-O

MOLECULAR WEIGHT :: 270.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - hemorrhage Behavioral - muscle weakness Gastrointestinal - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/30D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-H-benzimidazo<2,1-a>benzo<d,e>isoquinolin-7-one

Luminogren

EINECS 245-865-7

Luminor 2

12H-Naphtho<1',8',8'a-3,4,5>pyrido<1,2-a>benzimidazole-12-one

Luminor Yellow Green 490RT

Luminophor 2

Naphthoylenebenzimidazole

solvent yellow 184

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.