7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one

Modify Date: 2025-09-01 17:51:45

7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one Structure
7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one structure
 Common Name 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one
CAS Number 23749-58-8 Molecular Weight 270.28
Density 1.4g/cm3 Boiling Point 613.6ºC at 760mmHg
Molecular Formula C18H10N2O Melting Point N/A
MSDS N/A Flash Point 324.9ºC

 Use of 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one


AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

 Names

Name Yellow-green 490RT
Synonym More Synonyms

  Biological Activity

Description AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].
Related Catalog
References

[1]. Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042.  

 Chemical & Physical Properties

Density 1.4g/cm3
Boiling Point 613.6ºC at 760mmHg
Molecular Formula C18H10N2O
Molecular Weight 270.28
Flash Point 324.9ºC
Exact Mass 270.07900
PSA 34.37000
LogP 3.59190
Vapour Pressure 5.41E-15mmHg at 25°C
Index of Refraction 1.777

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD5380000
CHEMICAL NAME :
7H-Benzimidazo(2,1-a)benz(de)isoquinolin-7-one
CAS REGISTRY NUMBER :
23749-58-8
BEILSTEIN REFERENCE NO. :
0243687
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H10-N2-O
MOLECULAR WEIGHT :
270.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - hemorrhage Behavioral - muscle weakness Gastrointestinal - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 gm/kg/30D-I
TOXIC EFFECTS :
Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

7-H-benzimidazo<2,1-a>benzo<d,e>isoquinolin-7-one
Luminogren
EINECS 245-865-7
Luminor 2
12H-Naphtho<1',8',8'a-3,4,5>pyrido<1,2-a>benzimidazole-12-one
Luminor Yellow Green 490RT
Luminophor 2
Naphthoylenebenzimidazole
solvent yellow 184
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Chemsrc provides CAS#:23749-58-8 MSDS, density, melting point, boiling point, structure, etc. Its name is 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one>> amp version: 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one

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