8-Bromo-ATP

Modify Date: 2025-08-25 18:44:16

8-Bromo-ATP structure	Common Name	8-Bromo-ATP
	CAS Number	23567-97-7	Molecular Weight	586.07700
	Density	2.85g/cm3	Boiling Point	1009.7ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₅BrN₅O₁₃P₃	Melting Point	N/A
	MSDS	N/A	Flash Point	564.5ºC

Use of 8-Bromo-ATP

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3].

Name	[[(2R,3S,4R,5R)-5-(2-amino-8-bromopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Synonym	More Synonyms

Description	8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
In Vitro	8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma[3]. Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations[2]. Cell Viability Assay[3] Cell Line: MM 1.s cells Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM Incubation Time: 5 days Result: Showed cytotoxic to multiple myeloma.
References	[1]. Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder). Eur. J. Med. Chem. 23(5), 433-439 (1988). [2]. P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263(25):12288-94. [3]. Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21(4):306-14.

Density	2.85g/cm3
Boiling Point	1009.7ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅BrN₅O₁₃P₃
Molecular Weight	586.07700
Flash Point	564.5ºC
Exact Mass	584.90600
PSA	308.56000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.927

ATP disodium salt

CAS#:4691-96-7

~61%

8-Bromo-ATP

CAS#:23567-97-7

Literature: Gordeeva, L. S.; Kaminskii, Yu. L.; Rumyantseva, L. N.; Patokina, N. A.; Korsakova, N. A.; et al. Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 729 - 733 Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 771 - 776

Precursor 1
CAS#:4691-96-7 ATP disodium salt
DownStream 1
CAS#:23600-16-0 8-bromoadenosin...

8-bromoadenosine triphosphate

8-Bromoadenosine 5'-triphosphate

8-Bromo-ATP

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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 8-bromoadenosine 5'-triphosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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