(S,R,S)-AHPC-C10-NH2 dihydrochloride

Modify Date: 2025-08-25 09:39:36

(S,R,S)-AHPC-C10-NH2 dihydrochloride structure	Common Name	(S,R,S)-AHPC-C10-NH2 dihydrochloride
	CAS Number	2341796-75-4	Molecular Weight	686.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₅₃Cl₂N₅O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (S,R,S)-AHPC-C10-NH2 dihydrochloride

(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].

Name	(S,R,S)-AHPC-C10-NH2 dihydrochloride

Description	(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	VHL
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

Molecular Formula	C₃₃H₅₃Cl₂N₅O₄S
Molecular Weight	686.78
InChIKey	PVPQASMXRLTCBU-ABLBDAGXSA-N
SMILES	Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)CCCCCCCCCCN)C(C)(C)C)cc1.Cl
Storage condition	2-8°C

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