CXCR4 antagonist 6

Modify Date: 2025-08-24 19:43:53

CXCR4 antagonist 6 structure	Common Name	CXCR4 antagonist 6
	CAS Number	2304750-68-1	Molecular Weight	366.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₃₀N₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CXCR4 antagonist 6

CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].

Name	CXCR4 antagonist 6

Description	CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4:79 nM (IC50)
References	[1]. Li Z, et al. Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity. Eur J Med Chem. 2020;205:112537.

Molecular Formula	C₂₁H₃₀N₆
Molecular Weight	366.50

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CXCR4 antagonist 6

Use of CXCR4 antagonist 6

Names

CXCR4 antagonist 6 Biological Activity

Chemical & Physical Properties

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