UMB298

Modify Date: 2024-01-14 11:08:05

UMB298 structure	Common Name	UMB298
	CAS Number	2266569-73-5	Molecular Weight	479.01
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₁ClN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of UMB298

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].

Name	UMB298

Description	UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4:5193 nM (IC50)
In Vitro	UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1]. UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1]. UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1]. Cell Viability Assay[1] Cell Line: MOLM13 and MM cells Concentration: 0.01~10 μM Incubation Time: 50 days Result: Inhibited cells growth. Western Blot Analysis[1] Cell Line: MOLM13 cells Concentration: 1~10 μM Incubation Time: 2 hours Result: Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. RT-PCR[1] Cell Line: MOLM13 cells Concentration: 3 μM Incubation Time: 2 hours Result: Down-regulated MYC expression.
References	[1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801.

Molecular Formula	C₂₇H₃₁ClN₄O₂
Molecular Weight	479.01

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UMB298
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Price: ￥3690/10 mM * 1 mL in DMSO

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