Metipranolol
Modify Date: 2025-08-28 09:44:01
Metipranolol structure
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Common Name | Metipranolol | ||
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| CAS Number | 22664-55-7 | Molecular Weight | 309.40100 | |
| Density | 1.068g/cm3 | Boiling Point | 458.7ºC at 760mmHg | |
| Molecular Formula | C17H27NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 231.2ºC | |
Use of MetipranololMetipranolol is a nonselective and orally active β-adrenergic receptor antagonist. Metipranolol can be used for hypertension and glaucoma research[1][2]. |
| Name | metipranolol |
|---|---|
| Synonym | More Synonyms |
| Description | Metipranolol is a nonselective and orally active β-adrenergic receptor antagonist. Metipranolol can be used for hypertension and glaucoma research[1][2]. |
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| Related Catalog | |
| Target |
β1 adrenoceptor:8.3 (pA2) β2 adrenoceptor:8.4 (pA2) |
| In Vitro | In vitro β1- and β2-adrenoceptor antagonism is evaluated using the guinea pig atrium and the rat uterus, respectively. The respective pA2 values are 8.3 and 8.4[2]. Metipranolol significantly reduces iron/ascorbate-induced lipid peroxidation in rat brain homogenates with an IC50 value of 6.9 μM . Metipranolol also concentration-dependently inhibits sodium nitroprusside-stimulated lipid peroxidation in rat brain homogenates, displaying an IC50 value of 25.1 μM[3]. |
| In Vivo | At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice[1]. |
| References |
| Density | 1.068g/cm3 |
|---|---|
| Boiling Point | 458.7ºC at 760mmHg |
| Molecular Formula | C17H27NO4 |
| Molecular Weight | 309.40100 |
| Flash Point | 231.2ºC |
| Exact Mass | 309.19400 |
| PSA | 67.79000 |
| LogP | 2.66570 |
| Vapour Pressure | 3.29E-09mmHg at 25°C |
| Index of Refraction | 1.512 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2922509090 |
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| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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