JWD-065
Modify Date: 2025-08-27 03:50:50
JWD-065 structure
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Common Name | JWD-065 | ||
|---|---|---|---|---|
| CAS Number | 2250287-34-2 | Molecular Weight | 462.572 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H26N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JWD-065JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM. |
| Name | JWD-065 |
|---|
| Description | JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM. |
|---|---|
| References | 1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55. 2. Miduturu CV et al. Chem Biol. 2011;18:868–879. |
| Molecular Formula | C24H26N6O2S |
|---|---|
| Molecular Weight | 462.572 |
| InChIKey | OJKBELPVQXHUBY-UHFFFAOYSA-N |
| SMILES | C=CC(=O)Nc1cccc(C(=O)c2sc(Nc3ccc(N4CCN(C)CC4)cc3)nc2N)c1 |