β-Glucuronide-dPBD-PEG5-NH2

Modify Date: 2024-01-20 10:45:53

β-Glucuronide-dPBD-PEG5-NH2 Structure
β-Glucuronide-dPBD-PEG5-NH2 structure
 Common Name β-Glucuronide-dPBD-PEG5-NH2
CAS Number 2246363-68-6 Molecular Weight 1696.66
Density N/A Boiling Point N/A
Molecular Formula C78H101N7O35 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of β-Glucuronide-dPBD-PEG5-NH2


β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a prodrug of cIRCR201-dPBD, reduces side effects[1].

 Names

Name β-Glucuronide-dPBD-PEG5-NH2

 β-Glucuronide-dPBD-PEG5-NH2 Biological Activity

Description β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a prodrug of cIRCR201-dPBD, reduces side effects[1].
Related Catalog
Target

Drug-linker conjugates for ADC, Apoptosis[1]

References

[1]. Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

 Chemical & Physical Properties

Molecular Formula C78H101N7O35
Molecular Weight 1696.66
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Chemsrc provides β-Glucuronide-dPBD-PEG5-NH2(CAS#:2246363-68-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of β-Glucuronide-dPBD-PEG5-NH2 are included as well.>> amp version: β-Glucuronide-dPBD-PEG5-NH2

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