F-1

Modify Date: 2024-01-09 15:49:53

F-1 structure	Common Name	F-1
	CAS Number	2244775-31-1	Molecular Weight	519.02
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₇ClN₈O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of F-1

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].

Name	F-1

Description	F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333.

Molecular Formula	C₂₂H₂₇ClN₈O₃S
Molecular Weight	519.02
Storage condition	-20°C

F-1

Use of F-1

Names

F-1 Biological Activity

Chemical & Physical Properties