JI051
Modify Date: 2025-09-10 20:32:10
JI051 structure
|
Common Name | JI051 | ||
|---|---|---|---|---|
| CAS Number | 2234281-75-3 | Molecular Weight | 364.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H24N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JI051JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1]. |
| Name | JI051 |
|---|
| Description | JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | JI051 causes G2/M cell-cycle arrest[1]. JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1]. Cell Proliferation Assay[1] Cell Line: HEK293 cells Concentration: 0.1-10 µM Incubation Time: 24 hours Result: Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations. |
| References |
| Molecular Formula | C22H24N2O3 |
|---|---|
| Molecular Weight | 364.44 |
| InChIKey | CQZPBIZGVIRKOC-VAWYXSNFSA-N |
| SMILES | CCOc1ccccc1CCNC(=O)C=Cc1c[nH]c2c(OC)cccc12 |
| Storage condition | 2-8℃ |